A simple, scalable synthetic route to (+)- and (-)-pseudoephenamine.
نویسندگان
چکیده
A three-step synthesis of pseudoephenamine suitable for preparing multigram amounts of both enantiomers of the auxiliary from the inexpensive starting material benzil is described. The sequence involves synthesis of the crystalline monomethylimine derivative of benzil, reduction of that substance with lithium aluminum hydride, and resolution of pseudoephenamine with mandelic acid.
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عنوان ژورنال:
- Organic letters
دوره 15 21 شماره
صفحات -
تاریخ انتشار 2013